Hersteller Händler Dienstleister OEM

MEDIAGNOST GmbH

Aspenhaustr. 25 , 72770 Reutlingen
Deutschland

Telefon +49 7121 51484-0
Fax +49 7121 51484-10
contact@mediagnost.de

Dieser Aussteller ist Mitaussteller von
Baden-Württemberg International - Gesellschaft für int. wirtschaftl. u. wissenschaftl. Zusammenarbeit mbH

Messehalle

  • Halle 15 / G24
 Interaktiver Hallenplan

Hallenplan

MEDICA 2016 Hallenplan (Halle 15): Stand G24

Geländeplan

MEDICA 2016 Geländeplan: Halle 15

Unser Angebot

Produktkategorien

  • 03  Diagnostika
  • 03.02  Immunochemie (Immunologie)
  • 03.02.05  Hormonbestimmung, Geräte und Systeme für die

Hormonbestimmung, Geräte und Systeme für die

  • 03  Diagnostika
  • 03.02  Immunochemie (Immunologie)
  • 03.02.05  Hormonbestimmung, Geräte und Systeme für die
  • 03.02.05.01  Diagnostika / Kits für die Hormonbestimmung
  • 03  Diagnostika
  • 03.02  Immunochemie (Immunologie)
  • 03.02.05  Hormonbestimmung, Geräte und Systeme für die
  • 03.02.05.03  Kontrollmaterial für die Hormonbestimmung

Kontrollmaterial für die Hormonbestimmung

  • 03  Diagnostika
  • 03.02  Immunochemie (Immunologie)
  • 03.02.05  Hormonbestimmung, Geräte und Systeme für die
  • 03.02.05.04  Reagenzien für die Hormonbestimmung

Reagenzien für die Hormonbestimmung

  • 03  Diagnostika
  • 03.02  Immunochemie (Immunologie)
  • 03.02.07  Immun-Assay-Systeme
  • 03  Diagnostika
  • 03.02  Immunochemie (Immunologie)
  • 03.02.07  Immun-Assay-Systeme
  • 03.02.07.06  Enzymimmunoassay (EIA, ELISA, EMIT)

Enzymimmunoassay (EIA, ELISA, EMIT)

  • 03  Diagnostika
  • 03.02  Immunochemie (Immunologie)
  • 03.02.07  Immun-Assay-Systeme
  • 03.02.07.10  Heterogener Enzymimmunoassay

Heterogener Enzymimmunoassay

  • 03  Diagnostika
  • 03.02  Immunochemie (Immunologie)
  • 03.02.07  Immun-Assay-Systeme
  • 03.02.07.18  Mikropartikel-Enzymimmunoassay (MEIA)

Mikropartikel-Enzymimmunoassay (MEIA)

  • 03  Diagnostika
  • 03.02  Immunochemie (Immunologie)
  • 03.02.07  Immun-Assay-Systeme
  • 03.02.07.19  Photometrischer Assay

Photometrischer Assay

  • 03  Diagnostika
  • 03.02  Immunochemie (Immunologie)
  • 03.02.07  Immun-Assay-Systeme
  • 03.02.07.21  Radioimmunoassay (RIA)
  • 03  Diagnostika
  • 03.02  Immunochemie (Immunologie)
  • 03.02.09  Individuelle und spezielle Hormone

Individuelle und spezielle Hormone

  • 03  Diagnostika
  • 03.02  Immunochemie (Immunologie)
  • 03.02.09  Individuelle und spezielle Hormone
  • 03.02.09.01  Diagnostika / Kits für die Bestimmung von Wachstumshormonen

Diagnostika / Kits für die Bestimmung von Wachstumshormonen

  • 03  Diagnostika
  • 03.02  Immunochemie (Immunologie)
  • 03.02.09  Individuelle und spezielle Hormone
  • 03.02.09.02  Diagnostika / Kits für die Leptin-Bestimmung
  • 03  Diagnostika
  • 03.02  Immunochemie (Immunologie)
  • 03.02.18  Sepsis-Marker

Sepsis-Marker

  • 03  Diagnostika
  • 03.05  Infektionsimmunologie
  • 03.05.02  Hepatitisviren

Unsere Produkte

Produktkategorie: Diagnostika / Kits für die Hormonbestimmung

IGF-I ELISA E20, IGF-I RIA, IGF-R20, IGF-R22 (IGF-1)

The insulin-like growth factor-I (IGF-I) is a key factor in the regulation of proliferation and differentiation of several cells and tissues. The protein consists of 70 amino acids and has an apparent molecular weight of 7,649kDa.

The measurement of IGF-I is indicated in case of growth disturbances and suspicion of acromegaly.

The IGF-I concentration is influenced by several different factors, e.g. food intake, food  composition, hepatic diseases or obesity. But the predominant factor influencing the IGF-I content in human blood is the age. Thus, for assessing the test results age-specific reference values are necessary.

Mediagnost offers  3 different non extractive test systems for the measurement of human IGF-I in serum and plasma samples. All tsts are calibrated to the international standard  WHO 02/254  (conversion factor: 0,75) and are provided together with reference values for the evaluation of test results.

An overview of major assay characteristics is given in the table below. More detailed information is available in the package insert and for special requirements or questions please contact us directly by email or phone.

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Produktkategorie: Immun-Assay-Systeme

Coxsackievirus B3 Antibody

Coxsackievirus B3 (CVB3) of the enteroviruses of the family Picornaviridae is associated with a variety of acute and chronic forms of diseases including meningoencephalitis, insulin-dependent type I diabetes (IDDM) (Curr Diab Rep. 2010;10(5):350-6) and, importantly myocarditis (Eur Heart J. 2013;34(33):2636-48). Although most enterovirus infections are subclinical, these viruses are capable of inducing severe acute myocarditis which may lead to life-threatening arrhythmias. With the introduction of the in situ hybridization technique and polymerase chain reaction CVB3 RNA was not only detected in endomyocardial biopsies of patients with acute and chronic myocarditis but also in those suffering from dilated cardiomyopathy (Proc Natl Acad Sci U S A. 1987;84(17):6272-6; New Engl J Med 2000; 343, 1388-1398).

The pathogenic concept of enteroviral infection in the human heart was confirmed in various mouse models of CVB3-induced myocarditis, demonstrating that after acute infection CVB3, typically a cytolytic virus, is capable of evading the immunological surveillance, thus inducing a persistent infection of the myocardium in susceptible animals (Proc Natl Acad Sci U S A. 1992;89(1):314-8) which may also be associated with arrhythmias (FASEB J. 2013; 27(10):4108-21). The course of myocarditis proved to be highly dependent on cellular factors (J Virol. 2014 Jul 1;88(13):7345-56) and an early effective immune response including Natural Killer cells (J Pathol. 2014 May 5. doi: 10.1002/path.4369. [Epub ahead of print]). The dysregulation of the cellular metabolism in chronic CVB3 myocarditis involves processes of hemoxygenase-1 mediated oxidative stress (Cell Physiol Biochem. 2014; 33(1):52-66) and the induction of inflammatory cytokines and proteins such as connective tissue growth factor, CTGF (J Mol Med (Berl). 2008; 86(1):49-60) und osteopontin (Circ Res. 2009 104(7):851-9), which are decisive in remodelling processes of the heart following inflammation.

For the detection of CVB3 in human und murine tissue and cells Mediagnost provides an antibody, capable to detect highly specific and sensitive the viral capsid protein VP1 which was already shown in the following publications:

Freiberg F, Sauter M, Pinkert S, Govindarajan T, Kaldrack J, Thakkar M, Fechner H, Klingel K, Gotthardt M. Interspecies Differences in Virus Uptake versus Cardiac Function of the Coxsackievirus and Adenovirus Receptor. J Virol. 2014 Jul 1;88(13):7345-56.

Klingel K, Fabritius C, Sauter M, Göldner K, Stauch D, Kandolf R, Ettischer N, Gahlen S, Schönberger T, Ebner S, Makrigiannis AP, Bélanger S, Diefenbach A, Polić B, Pratschke J, Kotsch K. The Activating Receptor NKG2D of Natural Killer Cells Promotes Resistance against Enterovirus-Mediated Inflammatory Cardiomyopathy. J Pathol. 2014 May 5. doi: 10.1002/path.4369. [Epub ahead of print]

Ursu ON, Sauter M, Ettischer N, Kandolf R, Klingel K. Heme oxygenase-1 mediates oxidative stress and apoptosis in coxsackievirus B3-induced myocarditis. Cell Physiol Biochem. 2014;33(1):52-66.

Ettischer-Schmid N, Normann A, Sauter M, Kraft L, Kalbacher H, Kandolf R, Flehmig B, Klingel K.  A new monoclonal antibody (Cox mAB 31A2) detects VP1 protein of coxsackievirus B3 with high sensitivity and specificity. Virchows Arch
DOI 10.1007/s00428-016-2008-8

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Produktkategorie: Hepatitisviren

Hepatitis A Antigen ELISA

Enzyme immunoassay for the qualitative detection of Hepatitis A Virus antigen in human feces.

The early detection of HAV antigen in feces of patients with intestinal illness allows the establishment of hygiene measures to prevent the spreading of the virus.

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Produktkategorie: Diagnostika / Kits für die Leptin-Bestimmung, Diagnostika / Kits für die Hormonbestimmung

Leptin human (Leptin ELISA E07, E077), bioLEP ELISA, functional Leptin ELISA (L07) / Mouse Leptin ELISA, Rat Leptin ELISA (E06)

Leptin human
Leptin is a hormone predominately synthesized by  adipocytes. It consists of 167 amino acids and shows a molecular weight of 18,64kDa. Leptin is involved in the regulation of food intake and the Leptin concentration in human serum is mainly determined by body fat mass.

Mediagnost  offers three different Leptin test systems, all are calibrated against the international standard NIBSC 97/594. Further, we offer bioLEP, a test system to measure biologically active Leptin.  Here Leptin is measured by a combination of the leptin binding protein (extracellular part of the receptor) and a specific polyclonal antibody. This combination allows to measure only functional Leptin, which is able to bind to its receptor. An overview of major assay characteristics is given in the table below.
 
Leptin Mouse/Rat
Leptin is a hormone predominately synthesized by adipocytes. Leptin is involved in the regulation of food intake and the Leptin concentration in human serum is mainly determined by body fat mass.

Mediagnost Mouse/Rat ELISA is calibrated against the international standard NIBSC 97/626. An overview of major assay characteristics is given in the table below. More detailed information is available in the package insert and for special requirements or questions please contact us directly by email or phone.
 

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Produktkategorie: Radioimmunoassay (RIA)

IGF-I (IGF-1) RIA, IGF-II (IGF-2), IGFBP-3 RIA, Leptin RIA

Mediagnost Radio Immunoassays, RIA
IGF-R20 IGF-I RIA radioimmunoassay kit for 100 tubes
IGF-R22 IGF-I RIA-CT radioimmunoassay kit including 100 coated tubes
IGF-R30 IGF-II RIA radioimmunoassay kit for 100 tubes
IGF-R11 IGFBP-3 RIA-CT radioimmunoassay kit including 100 coated tubes
LEP-R44 Leptin RIA-CT radioimmunoassay kit including 125 coated tubes

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Produktkategorie: Enzymimmunoassay (EIA, ELISA, EMIT)

Pseudomonas aeruginosa Diagnostics

Enzyme immunoassay for the qualitative and semi-quantitative detection of human IgG  antibodies against the extracellular proteins alkaline protease, elastase and exotoxin A of Pseudomonas aeruginosa.

The measurement of these antibodies in addition to classical microbiology allows a more sensitive detection of pseudomonas infection. The diagnostic value of this test system was evaluated and published by  Kappler et al and Tramper-Stranders et al.  A general review regarding serology in the detection of pseudomonas aeruginosa infections was published by  Mauch und Levy.

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Produktkategorie: Immun-Assay-Systeme

Adipokins: Adiponectin, Resistin, Progranulin, Vaspin, Chemerin, Leptin

Adipokines
Fat cells are more than only engergy stores of the human body. The fatty tissue is an endocrinologically active organe. The hormones produced by fat cells influence and regulate food intake and utilization.

Mediagnost offers well characerized and validated enzyme-linked sorbant assays for multitude of adipokines and related proteins.

The species-specifity of the employed antibodies variies, thus the assays originally designed for the measurement of human hormones can also be used to detect the homolog animal proteins. An overview about the cross reactivities is shown in this PDF.

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Produktkategorie: Immun-Assay-Systeme, Hepatitisviren

Infectious Disease Diagnostics

Hepatitis A Virus (HAV)
Since the foundation Mediagnost produces the  Hepatitis A virus  and its specific  monoclonal antibodies for the production of  Mediagnost test systems as well as raw material for diagnostic companies.
Mediagnost offers test systems for the detection of anti-HAV antibodies (IgM and total IgG), HAV antigen and HAV RNA.

Pseudomonas aeruginosa
Mediagnost developed a test system for the detection of human IgG antibodies against antigens of Pseudomonas aeruginosa. This test system can be used as supplement for microbiological detection of  Pseudomonas aeruginosa infections in cystic fibrosis patients.

Coxsackievirus B3
In the field of enteroviruses Mediagnost developed a highly specific monoclonal antibody for the detection of the  Coxsackievirus B3. This  antibody can be used for different applications like immunohistology (paraffin), immunoflourescence, western blotting, flow cytometry and ELISA.

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Produktkategorie: Diagnostika / Kits für die Bestimmung von Wachstumshormonen

Growth: (hGH, GHBP, IGF-I, IGF-II, IGFBP-1, IGFBP-2, IGFBP-3, IGFBP-6, ALS) ELISA

Growth
A multitude of different factors regulates human growth. An important control cycle is  the system constisting of the Growth hormone and the Insulin-like Growth Factors with their Binding proteins.

Mediagnost offers test systems for the measurement of all important proteins of the Growth Hormone and IGF system.
hGH, GHBP, IGF-I, IGF-II, IGFBP-1, IGFBP-2, IGFBP-3, IGFBP-6, ALS

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Über uns

Firmenporträt

Die Mediagnost Gesellschaft für Forschung und Herstellung von Diagnostika GmbH wurde 1985 in Tübingen gegründet und entwickelte sich zu einem modernen und innovativen Biotechnologie-Unternehmen. Heute sind wir ein weltweit aktiver Diagnostikahersteller.

Im Technologiepark Tübingen-Reutlingen stehen uns modernste und bestens ausgestattete Räumlichkeiten für Forschung und Produktion unter optimalen Bedingungen zur Verfügung. Unsere Labore sind für L2/S2-Arbeiten zugelassen.

Die Herstellung unserer Diagnostika ist den strengen Qualitätsanforderungen für medizinische Produkte unterworfen. Mediagnost verfügt über ein Qualitätsmanagmentsystem, das nach ISO 13485 zertifiziert wurde.

Die Nähe zur Universität Tübingen und zahlreiche Kontakte zu anderen Forschungseinrichtungen ermöglichen uns von Beginn an den Technologietransfer von der wissenschaftlichen Front hin zum Kunden zu verwirklichen.

Das Arbeiten an Forschungsprojekten zur Entwicklung von Diagnostika mit höherer Effizienz und Sensibilität durch modernste Techniken sehen wir als eine wichtige Aufgabe, um unseren Kunden optimale Lösungen zu bieten.

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Unternehmensdaten

Umsatz

1-9 Mio US $

Exportanteil

max. 75%

Anzahl der Beschäftigten

20-49

Gründungsjahr

1985

Geschäftsfelder

Diagnostika